Cisplatin mechanism of hearing loss
WebMar 25, 2024 · Cisplatin is considered one of the most ototoxic pharmacologic agents, typically causing bilateral high frequency sensorineural hearing loss with progression to lower frequencies with continued exposure. Web2 days ago · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In particular, the …
Cisplatin mechanism of hearing loss
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WebFeb 11, 2024 · Cisplatin is used to treat a wide range of childhood cancers and cisplatin-induced hearing loss (CIHL) is a common and debilitating … Web1 hour ago · Fresh bamboo shoots (Chimonobambusa quadrangularis) are subjected to senescence (e.g., lignification and browning) during postharvest storage. This study …
WebJul 13, 2024 · “Around 60% to 80% of kids who get cisplatin have significant hearing loss,” Dr. Neuwelt explained. The impact of that hearing loss can be profound, he continued, including greatly increasing the risk …
WebCisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 patients diagnosed annually with these cancer types in the United States could be candidates for treatment with cisplatin. There is a 5-fold increase in the … WebThe incidence of ototoxicity induced by cisplatin ranges from 20% to 70%, and it usually manifests as a progressive, bilateral and irreversible hearing loss. Although the …
WebOct 8, 2012 · The mechanism of accumulation is unknown, but is thought to be by way of carrier-mediated transport in the case of cisplatin, ... Cisplatin-induced hearing loss is related to activation of STAT1. (A) …
WebApr 13, 2024 · Spankovich et al. showed a reduced cisplatin-related hearing loss by cold water irrigation in guinea pigs (Spankovich et al., 2016). In an alternative rodent experiment, the otoprotective effect of hypothermia applied through a custom-made cooling device was evaluated in a cochlea implantation situation. chinese lilburnWebMay 2, 2014 · Cisplatin-induced hearing loss is favoured either by preexisting afflictions like hypoalbuminemia, anaemia, renal failure, and noise-induced hearing loss or by risk … grandparents heartWebFeb 26, 2024 · The cisplatin ototoxicity occurs between 23% and 50% in adults and up to 60% in children [4,6]. However, some studies have reported elevated hearing thresholds in up to 100% of cisplatin-treated cancer patients [7,8], while it is estimated to be 63% with aminoglycosides and 6-7% with furosemide [9]. grandparents guardianshipWebSep 20, 2024 · The primary outcome was hearing loss according to American Speech-Language-Hearing Association (ASHA) criteria, assessed at baseline and 4-weeks after … grandparents helping with collegeWebJan 26, 2024 · Results from a new study may explain why many patients treated with the chemotherapy drug cisplatin develop lasting hearing loss. Researchers found that, in both mice and humans, cisplatin can be … chinese lilac bushWebJan 8, 2024 · Although cisplatin is one of the most commonly used antineoplastic drugs in clinic, it can lead to progressive and irreversible hearing loss. 21 At present, the recognized mechanism of cisplatin ototoxicity is that cisplatin can produce ROS, which can not only reduce the antioxidant defense molecules glutathione and antioxidant enzymes in ... grandparents helping pay for collegeWebJul 11, 2024 · The mechanism of cisplatin-induced hearing loss remains unclear. Oxidative stress injury, inflammation, apoptosis and autophagy play an important role in the pathogenesis of cisplatin-induced hearing loss ( Gentilin et al., 2024 ). chinese lilburn ga