Cisplatin nephropathy

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WebDiabetic nephropathy is characterized by inflammation, fibrosis, and oxidant stress, pathologic features that are shared by many other … WebKidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation can be diagnosed by blood tests. Nephrosis is non-inflammatory kidney disease.

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WebMay 1, 2008 · Cisplatin is one of the most widely used and most potent chemotherapy drugs. However, side effects in normal tissues and organs, notably nephrotoxicity leading to tubular and inflammation. Renoprotective approaches are being discovered, but the protective effects are mostly partial, suggesting the need for combinatorial strategies. WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … can inspiron n4010 be touchscreen

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WebJul 22, 2024 · Cisplatin nephropathy is a representative chemotherapeutic agent-related AKI. The molecular mechanisms underlying cisplatin-induced AKI have long been the subjects of research, and a number of studies have demonstrated the involvement of mitochondrial dysfunction, oxidative stress, inflammation, and apoptosis in renal tubular … WebSep 15, 2008 · Cisplatin (Platinol) Chronic interstitial nephritis, tubular cell toxicity: Interferon-alfa (Intron A) Glomerulonephritis: Methotrexate: Crystal nephropathy: … WebNov 26, 2024 · Cisplatin is one of the commonly used anticancer drugs in clinic chemotherapy, but drug resistance is a major therapeutic obstacle for successful treatment. While ginkgolic C17:1 alone induced autophagy and apoptosis in the human hepatoblastoma cells HepG2, it was found to paradoxically inhibit cisplatin-induced … five days in london summary

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WebNational Center for Biotechnology Information WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury. five days in london fivedayslunch

"WebOct 1, 2024 · We identified Compound-6c(Cpd-6c) as having the best activity and examined its protective effect against cisplatin nephropathy both in vivo and in vitro in cisplatin-stimulated tubular epithelial cells (TECs). Our results showed that Cpd-6c restored renal function more effectively than Ru, as evidenced by reduced blood urea nitrogen and … " - Cisplatin nephropathy

Cisplatin nephropathy

WebCisplatin ATN AKI, hypomagnesemia, renal sodium Chronic interstitial ﬁbrosis and cyst formation wasting, CKD Ifosfamide ATN Fanconi syndrome (partial or complete) AKI ESRD Methotrexate Crystal nephropathy Nonoliguric AKI Pemetrexed ATN AKI AIN CKD Tubular atrophy and interstitial ﬁbrosis Nephrogenic diabetes insipidus Ipilimumab AIN AKI WebDec 13, 2024 · Cisplatin and carboplatin are platinum-based antineoplastic agents. Approximately 30% of patients receiving cisplatin have acute kidney injury (AKI), and it is not unusual for subsequent treatment to be limited [].On the other hand, carboplatin, which was developed as a derivative of cisplatin in the same platinum formulation, is …

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WebSide effect and toxicity management Prophylaxis and treatment Prevention and management of cisplatin nephrotoxicity ID: 184 v.3 Endorsed This document is an … WebCisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin …

WebSep 15, 2008 · In thrombotic microangiopathy, organ damage is caused by platelet thrombi in the microcirculation, as in thrombotic thrombocytopenic purpura. 30 Mechanisms of renal injury secondary to drug-induced... WebJul 22, 2024 · It is important to note that for many malignancies, cisplatin is used in combination with other drugs that may also be nephrotoxic. Cellular toxicity — Cisplatin (cis-diamminedichloroplatinum II [CDDP]), a platinum compound that is predominantly …

WebApr 12, 2024 · In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic … WebBackground A strategy for preventing cisplatin nephrotoxicity due to enhanced oxidative stress and inflammatory response is highly desirable. Thioredoxin-1 (Trx), an endogenous redox-active protein,

WebNov 11, 2024 · Cisplatin (CDDP), a platinum drug, has been universally utilized to treat bladder cancer, ovarian cancer and other solid tumors ( Dasari and Tchounwou, 2014 ). However, the dominant factor restricting the clinical use of cisplatin is its nephrotoxicity ( Zhu et al., 2015 ).

WebProphylaxis and treatment Prevention and management of cisplatin nephrotoxicity ID: 184 v.3 Endorsed This document is an evidence based summary to complement treatment protocols and includes background and rationale for specific point of care actions. It is not intended to be a comprehensive literature review of all available evidence. On this page can insta chat be screenshootedWebCisplatin was the first platinum compound to be introduced as a chemotherapeutic agent with antineoplastic activity against a wide variety of solid tumors. Renal impairment with … can instagram followers see what you likeWebAug 14, 2024 · Nephrotoxicity associated with cisplatin administration is common and unwanted adverse effect which has significantly restricted its clinical use [ 1 ]. Both acute and chronic nephrotoxicities associated with cisplatin tend to occur more frequently at higher doses or especially after repeated administration [ 2 ]. five days in summerWebMyeloma cast nephropathy is an obstructing disorder of renal tubules, caused by precipitation of Bence Jones proteins. Myeloma-like cast nephropathy (MLCN) has … can instagram posts be scheduledWebCisplatin-nephropathy model mice exhibited elevated levels of serum IS accompanied by elevated levels of blood urea nitrogen and serum creatinine. Furthermore, intraperitoneal administration of IS in mice promoted tumor growth and metastasis. Finally, we found that the MasR agonist Ang-(1-7) suppressed the IS-mediated effects on cell ... five days in may bookWebIn order to confirm the additional adverse effects of KU55933 on cisplatin-induced DNA damage and to elucidate the For all groups, data are means ± SEM, *p < 0.05 vs control, # p < 0.05 vs ... can instagram reels be longer than 30 secondsWebApr 12, 2024 · Cisplatin is a highly effective anti-cancer agent used in the treatment of solid organ tumors, such as head and neck, lung, breast, testis, and ovarian cancers 1, 2. Although cisplatin has... five days inside wiki