Insulin-stimulated glut4 translocation

Author: xjru

August undefined, 2024

Nettet20. jun. 1995 · The acute effects of contraction and insulin on the glucose transport and GLUT4 glucose transporter translocation were investigated in rat soleus muscles by ... Nettet10. nov. 2014 · Although insulin-stimulated glucose uptake in tissues, including BAT, is well-characterized by the phosphoinositide 3-kinase-phosphoinositide–dependent kinase-1-Akt (PI3K–PDK1–Akt) pathway as resulting in the rapid translocation of glucose transporter 4 (GLUT4) from intracellular vesicles to the cell membrane (Huang and …

Insulin-stimulated GLUT4 translocation requires the CAP …

NettetInsulin-regulated trafficking of the facilitative glucose transporter GLUT4 has been studied in many cell types. The translocation of GLUT4 from intracellular membranes to the … Nettet24. nov. 1995 · There is evidence to suggest that PI3-kinase may be an intermediary molecule facilitating insulin-stimulated GLUT4 translocation(29, 30, 31, 32).When … pilothelme

The TC10-interacting protein CIP4/2 is required for insulin-stimulated ...

NettetInsulin-stimulated glucose uptake is primarily mediated by the transporter isoform GLUT4, which is predominantly expressed in mature skeletal muscle and fat tissues. … NettetSimilarly, in vitro incubation of differentiated myotubes with alcohol acutely inhibited insulin-stimulated GLUT4 translocation and this response is dose-dependent . … NettetThe presence of wortmannin, a pharmacological inhibitor of PI-3-Kinase, potentially inhibited insulin-stimulated GLUT4 translocation to cell periphery in L6-GLUT4 myc … pilot hda

Impact of Alcohol on Glycemic Control and Insulin Action

NettetNational Center for Biotechnology Information Nettet5. okt. 2024 · The glucose transporter GLUT4 that is localized in the plasma membrane mediates the insulin-stimulated glucose transport in skeletal muscle and adipose tissue [ 2, 3 ]. In unstimulated cells, GLUT4 molecules are sequestered in specialized intracellular compartments, termed GLUT4 storage vesicles. gunilla kallinNettet10. feb. 2013 · * Studied signaling mechanism of insulin-stimulated GLUT4 translocation in vitro * Studied the role of IKKepsilon on … pilot hds

"NettetPalmitoylation of GLUT4 at Cys 233 by palmitoyltransferase zinc finger DHHC-type containing 7 (DHHC7) is critical for insulin-stimulated membrane translocation (232, … " - Insulin-stimulated glut4 translocation

Insulin-stimulated glut4 translocation

Contraction stimulates translocation of glucose transporter GLUT4 …

Nettet14. mar. 2024 · It is shown that phosphatidylcholine-specific phospholipase C (PC-PLC) plays an important role in insulin-mediated downregulation of GLUT4 and that PCho may serve as a signaling molecule. PDF View 1 excerpt, cites background Ubiquitin-like processing of TUG proteins as a mechanism to regulate glucose uptake and energy …

Did you know?

NettetGLUT4 Translocation Assay The surface GLUT4 level in non-permeabilized L6-GLUT4 myc myotubes was measured by an antibody-coupled colorimetric assay [ 29 ]. After indicated treatments with BSD, myotubes were fixed in 3% paraformaldehyde and quenched in 100 mM glycine. NettetBackground: Cell surface levels of glucose transporter Glut4 are tightly controlled in adipocytes.Results: The effects of insulin and differentiation on the trafficking kinetics …

NettetGLUT4 is the insulin-responsive glucose transporter responsible for postprandial glucose clearance. In muscle and adipose cells, GLUT4 is packaged in vesicles that are released upon stimulation of the insulin receptor and, in the case of muscle, also in response to exercise (Bryant et al., 2002). NettetGLUT4. Glucose transporter type 4 ( GLUT4 ), also known as solute carrier family 2, facilitated glucose transporter member 4, is a protein encoded, in humans, by the …

Nettet19. apr. 2001 · The stimulation of glucose uptake by insulin in muscle and adipose tissue requires translocation of the GLUT4 glucose transporter protein from intracellular … Nettet9. nov. 2001 · Furthermore, expression of the dominant-interfering TC10/T31N mutant completely disrupted cortical actin and prevents any insulin-stimulated actin …

Nettet17. jun. 2024 · Exploring the therapeutic potential of modulating GLUT4 trafficking requires a thorough understanding of the molecular machineries and signalling networks implicated in translocating GLUT4 from...

Nettet29. nov. 2024 · These data are consistent with reduced insulin-stimulated GLUT4 translocation reported in larger fat cells 60,61, studies of hypertrophic adipocytes … pilot hddNettetRegulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide Mol Cell Biol. 1998 Sep;18(9):5457-64. doi: 10.1128/MCB … pilot health risksNettet22. jan. 2024 · The concept of intrinsic transport activity of GLUT4, that is, the ability of each GLUT4 transporter to transport glucose, was developed because of observed … pilot hd5000Nettet7. des. 2024 · GLUT4 (the insulin sensitive glucose transporter) translocates from the endosome stores to the sarcolemmal membrane for glucose assimilation following insulin stimulation, while GLUT1 is more localized in the cytosol and less dominant in the sarcolemma [ 8, 9, 10 ]. gunilla johansson torsbyNettet12. jan. 2024 · Insulin-stimulated GLUT4 translocation is essential for maintenance of glucose hemostasis in human body. The dysfunction of this process promotes insulin … pilot heilbronnNettet5. okt. 2024 · Insulin stimulates glucose uptake in adipose tissue and skeletal muscle by inducing plasma membrane translocation of the glucose transporter GLUT4. Although … gunilla jonssonNettet20. aug. 2024 · DS20060511 induced GLUT4 translocation and stimulated glucose uptake into differentiated L6-myotubes ... G. W. et al. Insulin-stimulated translocation of the HepG2/erythrocyte-type glucose ... gunilla jonsson nyköping