WebJan 24, 2024 · IRF3- and IRF9-dominant regions were characterized by the enriched ISRE motif and lower frequency of accessible chromatin. Enrichment analysis and the machine … WebIRF3 is constitutively expressed and resides in the cytoplasm, but gets internalized to the nucleus upon phosphorylation. Here, IRF3 will initiate the transcription of IFNβ, which in …
IRF3 Gene - GeneCards IRF3 Protein IRF3 Antibody
WebOct 6, 2024 · IRF3 is activated downstream of all anti-viral PRRs through phosphorylation by IκB kinase (IKK)-related protein kinases, TANK-binding Kinase (TBK1) and IKKε, resulting in its dimerization and translocation into the nucleus in association with CREB-binding protein (CBP)/p300 to bind and transactivate the expression of target genes, such as TI-IFNs … WebIRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association … flow audi
Cellular functions of cGAS-STING signaling - ScienceDirect
Webdna-binding ELISAs for activated IRF-3 transcription factors. TransAM ® Kits are DNA-binding ELISAs that facilitate the study of transcription factor activation in mammalian … WebWith the use of ChiP-seq and transcriptomic measurements in WT versus ifnar2/2 versus ifnar2/2irf32/2 macrophages responding to intracellular dsRNA, we confirmed the known ISGF3 DNA-binding motif ... WebJul 30, 2015 · The N-terminus of TRIF recruits TRAF-3 and phosphorylates IRF3, leading to the induction of type-1 IFN [ 12, 13] ( Figure 1 ). The differential regulation of gene activation at the transcriptional level is indicative of a precisely controlled binding of selective transcription factors to DNA motifs at the promoter of these genes. greek dance competition