WebSep 16, 1999 · Synthetic Studies of Tedanolide, a Marine Macrolide Displaying Potent Antitumor Activity. Stereoselective Synthesis of the C (13)−C (23) Segment. Organic Letters 2005, 7 (12) , 2341-2344. DOI: 10.1021/ol050569a. Lisa D. Julian,, Jason S. Newcom, and, William R. Roush. Total Synthesis of (+)-13-Deoxytedanolide. WebTedanolide C32H50O11 - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National Institutes of Health
ORGANIC LETTERS Synthesis of a Fully Functionalized …
WebTedanolide is a marine natural product isolated from sponge Tedania ignis by Schimtz et al. in 1984.1,2 The sponge showed potent cytotoxicity and in vivo tumor inhibition activity. The isolation process is shown in Scheme 1.1. Notice the extreme low isolated yield of tedanolide, which suggests that it may be a metabolite of some ... WebDie Tedanolide sind biologisch aktive Polyketide, deren Makrolaktonring aus einem primären Alkohol aufgebaut ist. Da Polyketidumwandlungen nur sekundäre Alkohole erzeugen, postulierte Taylor,... sparrows lake charles
Studies Toward the Stereoselective Total Synthesis of …
Webapproaches to tedanolide and its analogues. By using a straightforward retrosynthetic disconnection of the tedanolide skeleton involving cleavage at the lactone moiety and scission at the C12-C13 bond, we were able to generate the precursors 2 and 3 (Scheme 1). Recently, we reported two approaches to the C1-C12 fragment of tedanolide 2, both of ... WebDec 1, 2006 · Tedanolide is a unique 18-membered macrolide where lactonization occurs at a primary hydroxyl group instead of a common secondary one, and this class of … WebCytotoxicity-guided fractionation of the crude methanol extract of a marine sponge, Ircinia sp., yielded tedanolide C (1), a new 18-membered macrolide. The structure was solved … techmates